Fig. 5
From: Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
Transfer of R123 into the fetal (E19) brain and cerebrospinal fluid (CSF). Concentration ratios of R123 in the E19 CSF (a, b) or brain (c, d) compared to E19 plasma (blood) 30–120 min post-maternal injection. The CSF/plasma (a) and brain/plasma (c) concentration ratios are shown compared to the time post-injection that each individual fetus was sampled (see Methods). For comparison the ratios at E19 are plotted with ratios obtained for P4, P14 and adult rats (b, d; data from Figs. 2 and 3). The E19 concentration ratios taken closest to the 30 min post-injection time-point of postnatal values are shown as X. Age is indicated on the X-axis (b, d)