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Fig. 9 | Fluids and Barriers of the CNS

Fig. 9

From: Quantitatively relating brain endothelial cell–cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program

Fig. 9

Junction Presentation versus PR Area. The correlation between PR area and the percent (a, b) and count (C,D) each continuous (Cont.), discontinuous (Disc.), and no junction (No Junct.) regions at the cell edge that are co-localized with a PR for ZO-1 and VE-cadherin. All results were fit using a linear regression. N = 105 for (a, c) and 124 (b, d), where N is the number of PRs. The Cont., No. Junct. Disc., Punctate, and Perp. R2 values are as follows: 0.001, 0.019, 0.039, 0.044, and 2.11E−4 for (a), 0.008, 0.009, 0.007, 0.010, and 9.80E−5 for (b) 0.213, 0.662, 0.617, 0.510, and 0.546 for (c), 0.143, 0.451, 0.493, 0.387, and 0.310 for (d). See Additional file 1: Table S4 for a summary of the statistical analysis for slope significance

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Fluids and Barriers of the CNS

ISSN: 2045-8118