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Fig. 8 | Fluids and Barriers of the CNS

Fig. 8

From: Quantitatively relating brain endothelial cell–cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program

Fig. 8

Permeated region and junction presentation analysis. The average number of each PR type per image is presented in a while the average size of each PR type is presented in b. N = 15 for (a) where N is the number of images. 11 ≤ N ≤ 247 for (b) where N is the number of PRs. Percentage (c, d) and count (e, f) of ZO-1 (left column) and VE-cadherin (right column) junctions along the cell edges co-localized with PRs. N = 105 for VE-cadherin and 126 for ZO-1, where N is the number of PRs. The co-localization of ZO-1 (g) and VE-cadherin (h) with PRs. N = 9, where N is the number of images. The Kruskal–Wallis test with a Dunn’s multiple comparison test was used to calculate significant differences for a–f and a Mann–Whitney test was used for (g, h), where ns = p > 0.05, *p < 0.05, **p < 0.01, and ****p < 0.0001

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Fluids and Barriers of the CNS

ISSN: 2045-8118