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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

Fig. 5

AQP1 and NKCC1 are present in leptomeningeal vascular endothelia of the spinal cord. Micrographs of paraffin sections obtained from the spinal cord of adult mice (P90) and immunolabeled for AQP1 and NKCC1 (brown). AQP1 immunoreactivity is predominantly located in C fibers in the dorsal horns of the spinal cord (a, arrowheads), whereas NKCC1 is observed throughout the spinal cord grey matter (d). b, e High magnification of the area delimited by the blue rectangle in a and d, respectively, show AQP1int+/NKCC1+ leptomeningeal vessels (arrows) in the spinal cord. c, f High magnification micrographs of the area delimited by the green squares in b and e show AQP1int+/NKCC1+ cells in the vascular endothelium, restricted to the subarachnoid space along the spinal cord (curved arrowheads). DRG, dorsal root ganglia; SAS, subarachnoid space. Scale bars: a, d 1 mm; b, e 100 μm; c, f 50 μm

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Fluids and Barriers of the CNS

ISSN: 2045-8118