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Table 1 Clinical and demographic characteristics of the study population

From: Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient

 FemaleMalep
All patients, n (%)718 (59.4)491 (40.6) 
 Age, years: median (IQR)44 (33–58)48 (35–65)0.0002
MS, n (%)204 (68.7)93 (31.3) 
 Age, years: median (IQR)37.0 (30.0–45.0)35.0 (29.0–45.0)0.5289
 Relapsing–remitting: n16372 
 Secondary progressive: n2311 
 Primary progressive: n1810 
OIND, n (%)132 (47.0)149 (53.0) 
 Age, years: median (IQR)52.5 (39.0–63.6)52.0 (38.5–69.0)0.5070
 Diagnosis (n)Infectious diseases (17)
Autoimmune neurological diseases (46)
Paraneoplastic CNS neurological syndromes (4)
Aseptic or bacterial meningitis; aseptic encephalitis or myelitis (16)
Inflammatory demyelinating neuropathies (40).
Inflammatory neuritis (9)
Infectious diseases (15)
Autoimmune neurological diseases (26)
Paraneoplastic CNS neurological syndromes (10)
Aseptic or bacterial meningitis; aseptic encephalitis or myelitis (26)
Inflammatory demyelinating neuropathies (59) Inflammatory neuritis (13)
 
NIND, n (%)146 (49.2)151 (50.8) 
 Age, years: median (IQR)52.0 (38.8–68.0)53.0 (37.0–66.0)0.7482
 Diagnosis (n)CNS expansions (14)
Vascular diseases (50)
Neurodegenerative diseases (20)
Hereditary/metabolic encephalopathies (4)
Unconsciousness (18)
Non-inflammatory PNS involvement (16)
CSF flow abnormalities (5)
Dementia and Parkinson syndromes (19)
CNS expansions (13)
Vascular diseases (51)
Neurodegenerative diseases (27)
Hereditary/metabolic encephalopathies (2)
Unconsciousness (10)
Non-inflammatory PNS involvement (27)
CSF flow abnormalities (2)
Dementia and Parkinson syndromes (19)
 
UNK, n (%)236 (70.7)98 (29.3) 
 Age, years: median (IQR)42.4 (31.0–58.0)51.0 (40.8–66.0)0.0002
  1. Age distributions were compared with Mann–Whitney u-test
  2. CNS central nervous system, CSF cerebrospinal fluid, MS multiple sclerosis, NIND non-inflammatory neurological diseases, OIND other inflammatory neurological diseases, PNS peripheral nervous system, UNK unknown-neurological diagnosis