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Table 3 Concentrations of the treatments added to the aCSF for ventriculo-cisternal perfusion and variable rate infusion experiments

From: Cerebrospinal fluid dynamics modulation by diet and cytokines in rats

Treatment

Supplier

Dose (ng/ml)

Reference based on reported levels in CSF of IIH patients

Hydrocortisone

Sigma-Aldrich, Dorset, UK (H0135)

500

Sinclair et al. [19]

TNF-α

Sigma-Aldrich, Dorset, UK (H8916)

0.1

Hayakata et al. [16]

IL-6

Life Technologies, Paisley, UK (10398-H08H-5)

0.1

Reihani-Kermani et al. [18]

IL-17

Miltenyi Biotech Ltd, Woking, UK (130-093-959)

0.1

Li et al. [41]

CCL2

Cambridge Bioscience, Cambridge, UK (00220-0-100)

50

Dhungana et al. [1]

IL-1β

Miltenyi Biotech Ltd, Woking, UK (130-093-897)

0.1

Hayakata et al. [16]

Leptin

Sigma-Aldrich, Dorset, UK (L4146)

100

Dhungana et al. [1]