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Table 6 TMS responses and motor parameters before and after lumbar puncture in divided subgroups

From: Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

 

Pre-LP

Post-LP

  

TT+ mean ± SD

TT− mean ± SD

p-valuea

TT+ mean ± SD

TT− mean ± SD

p-valuea

TT+b p-value

TT−b p-value

Upper limb SP (ms)

51.6 ± 18.6

62.2 ± 16.5

0.161

48.0 ± 23.3

61.0 ± 15.6

0.093

0.110

0.779

Upper limb RMT (%-MSO)

25.3 ± 4.4

27.6 ± 4.2

0.436

24.6 ± 3.4

27.7 ± 3.9

0.077

0.287

0.831

Upper limb EF (V/m)

80.1 ± 14.3

84.1 ± 12.1

0.489

76.4 ± 16.1

91.3 ± 12.5

0.024*

0.407

0.075

Lower limb RMT (%-MSO)

42.3 ± 8.4

42.0 ± 7.3

0.387

43.1 ± 8.0

43.0 ± 9.1

0.436

0.388

0.252

Lower limb EF (V/m)

158.7 ± 47.4

139.9 ± 41.3

0.387

138.4 ± 32.1

140.0 ± 39.2

0.931

0.327

0.767

IO-max (mV)

5.2 ± 2.9

4.3 ± 2.5

0.470

5.1 ± 3.3

4.5 ± 2.3

1.000

0.767

0.735

IO-50 (%-MSO)

34.1 ± 3.2

38.0 ± 7.6

0.299

35.9 ± 3.8

37.1 ± 6.3

0.873

0.173

0.310

IO-slope

2.5 ± 1.2

2.7 ± 1.3

0.837

3.4 ± 1.6

2.6 ± 1.0

0.470

0.028*

1.000

TSG (score)

42.8 ± 21.4

64.6 ± 24.5

0.077

51.9 ± 25.8

64.2 ± 24.4

0.340

0.018*

0.674

Gait velocity (m/s)

0.74 ± 0.24

0.99 ± 0.24

0.040*

0.90 ± 0.24

1.01 ± 0.26

0.340

0.008*

0.314

Steps (number)

25.8 ± 7.5

20.5 ± 4.6

0.077

22.8 ± 5.5

20.6 ± 4.2

0.340

0.011*

0.575

BBT (pcs)

49.4 ± 14.2

59.6 ± 8.6

0.113

50.7 ± 11.2

58.6 ± 7.8

0.136

0.952

0.438

GPT (s)

111.1 ± 22.4c

125.7 ± 43.7

0.481c

109.9 ± 26.9c

117.1 ± 21.2

0.321c

0.889c

0.779

  1. n = 18
  2. SP silent period, RMT resting motor threshold, EF electric field, IO-max the maximum value of the input–output curve, IO-50 the mid-point of the input–output curve, IO-slope the slope of the input–output curve, TSG total score of gait, BBT Box and Block Test, GPT Grooved Pegboard Test, Pre-LP before lumbar puncture, Post-LP after lumbar puncture, TT+ patients who improved at least 10% in the TAP test, TT− patients who improved under 10% in the TAP test
  3. * Indicates significant differences (p < 0.05)
  4. aComparison of between-group differences before and after the LP (Independent-Samples Mann–Whitney U test)
  5. bComparison of within-group differences before and after the LP (Wilcoxon signed-rank test)
  6. cOne outlier excluded from statistical analyzes
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Fluids and Barriers of the CNS

ISSN: 2045-8118