Skip to main content
Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro

Fig. 2

PSEN1-BMECs show lower P-gp and MRP1 activity than control-BMECs and PSEN2-BMECs. a Representative micrograph pictures of P-gp, BCRP and MRP1 immunostaining in BMECs derived from the control, PSEN1, and PSEN2 iPSC lines. Scale bar = 50 µm. Cell uptake assay of drug efflux substrate for assessing P-gp (b), BCRP (c) and MRPs (d) activity. Note the higher P-gp and MRPs efflux substrate uptake in PSEN1-BMECs compared to the two other iPSC lines, as well as an absence of increased drug efflux substrate in PSEN1 following P-gp and MRPs inhibition by cyclosporine A and MK571 respectively. N = 3/group, * and ** denote P < 0.05 and P < 0.01 respectively

Back to article page