Fig. 4
From: Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging
Aging alters the CSF outflow kinetics at the nasal route. a NIRF intensity-time profile at the main CSF outflow regions for young (Y) and old (O) mice after 5 μL intracisternal injection at 0.5 μL/min. b Time to reach peak intensity (Tmax) for nasal (N) and spinal cord (SC) regions. (c) Rate of rise of the upward linear slope using data as in panel A. d Peak intensities (Imax). e Half time (t1/2) for the elimination phase. f Plasma 125I-BSA levels after intracisternal injection. g NIRF-Albumin intensity for the dorsal and ventral brain surfaces after 150 min in the old mice. h Comparison of dorsal and ventral brain surfaces intensities between young and old mice. i Comparison of dorsal to ventral brain surface intensities ratios between young and old mice. Values are mean ± SD, N = 5–6 mice per group. Young male mice (2–3 months--old). Old male mice (11–13 months-old). AU (arbitrary units)