Fig. 1
From: Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging
Kinetic analysis of CSF outflow shows mainly nasal and spinal routes. a Experimental set-up to image NIRF-Albumin in vivo in the prone mice. b NIRF images after 5.0 or 0.5 μL intracisternal injection at 0.5 μL/min at 30 min. c Regions of interest (ROIs) selected for analysis. This spinal ROI was used only at 30 min. d NIRF intensity-time profile for each ROI after a 5 μL intracisternal injection at 0.5 μL/min for a mouse. e Standardization of data by dividing intensities at each time point by the peak intensity (It/Ip ratio). Mean values were used for each ROI from 5 mice. f Time to reach peak intensity (Tmax) for main ROIs. g Rate of rise of the upward linear line using data as in panel E. h Peak intensities (Imax). i Half time (t1/2) for the falling phase (elimination) from the peak. Values are mean ± SD, N = 5 young male mice. AU (arbitrary units)