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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury

Fig. 7

Proposed mechanism by which water TT protects the BSCB after SCI. Barrier integrity is compromised by the disruption of interendothelial TJs and AJs, as well as overall mechanical damage to vessels after SC. This results in the infiltration of immune cells and neurotoxic products, causing nerve cell death. Water treadmill training prevents disruption of the BSCB by protecting the residual BSCB structure, promoting vascular regeneration and inhibiting MMP-2/9 expression following SCI

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Fluids and Barriers of the CNS

ISSN: 2045-8118