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Table 2 The median and interquartile range (25th–75th percentile) of the transfer constant (Ktrans) and the number of good fits measured in various regions-of-interest (ROIs)

From: Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs

ROI

ETM Ktrans [min−1]

25th–75th percentile

Number of good fits from a total of 20

Secretory

.22*

.17–.33

19

 NH

.40*

.29–.63

19

 ME

.048*

.032–.11

19

 PG

.078*

.033–.12

16

Sensory

.026*

.021–.036

10

 SFO

1.8 · 10−3

− .69 · 10−3–25·10−3

8

 OVLT

.019*

.0091–.034

17

 AP

10 · 10−3*

.87 · 10−3– 80·10−3

10

 

Patlak Ktrans [min−1]

  

White matter

4.1 · 10−7*

.52 · 10−7–9.3 · 10−7

N.A.†

Gray matter

13 · 10−7*

5.1 · 10−7–17 · 10−7

N.A.†

  1. NH neurohypophysis, ME median eminence, PG pineal gland, SFO subfornical organ, OVLT organum vasculosum of the lamina terminalis, AP area postrema
  2. * Ktrans significantly larger than 0 (p < .05)
  3. † Goodness of fit not applicable as a voxel wise Patlak method followed by noise correction using histogram approach was used
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Fluids and Barriers of the CNS

ISSN: 2045-8118