Fig. 3
From: Identification and in vivo characterization of a brain-penetrating nanobody
Evaluation of the dose–response relationship of NT. a TLR4−/− mice body temperature measurements after ICV injections of the indicated doses of NT or saline (*p = 0.0249, ****p < 0.0001). Bar graphs represent mean ± SEM (n = 3 per group for saline and NT (5 pmol) and n = 2 for NT (10 pmol)). b TLR4−/− mice body temperature measurements after intravenous injections of the indicated doses of Nb62 or negative control nanobody fused to NT (****p < 0.0001). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: two-way ANOVA with Dunnett multiple comparisons test compared to saline or negative control nanobody