Fig. 1
From: Identification and in vivo characterization of a brain-penetrating nanobody
Binding of anti-mTfR nanobodies to mouse and chimeric human TfR. Binding of anti-mTfR to biotinylated mTfR a or biotinylated chimeric human TfR with mouse apical domain b immobilized on streptavidin biosensors. Biosensors were dipped in 1 µg/ml TfR, followed by 100 nM of nanobody. All nanobodies bind mTfR (A) of which only one, Nb62, was also able to bind the chimeric TfR (B)