TY - JOUR AU - Wouters, Y. AU - Jaspers, T. AU - De Strooper, B. AU - Dewilde, M. PY - 2020 DA - 2020/10/14 TI - Identification and in vivo characterization of a brain-penetrating nanobody JO - Fluids and Barriers of the CNS SP - 62 VL - 17 IS - 1 AB - Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to the discovery of an anti-transferrin receptor nanobody that is able to deliver a biologically active peptide to the brain via receptor-mediated transcytosis. SN - 2045-8118 UR - https://doi.org/10.1186/s12987-020-00226-z DO - 10.1186/s12987-020-00226-z ID - Wouters2020 ER -