Fig. 5

a Permeability coefficient (P) of mannitol and sucrose in the Transwell model with TEER value of 1812 ± 54 Ω cm2 (n = 3). b Permeability coefficient (P) of mannitol and sucrose in the vivo model (n = 6). ****p < 0.0001, analyzed by Student’s unpaired t-test (two-tailed). c In vitro and in vivo correlation of mannitol and sucrose based on the permeability coefficients