Fig. 5From: LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrosea Permeability coefficient (P) of mannitol and sucrose in the Transwell model with TEER value of 1812 ± 54 Ω cm2 (n = 3). b Permeability coefficient (P) of mannitol and sucrose in the vivo model (n = 6). ****p < 0.0001, analyzed by Student’s unpaired t-test (two-tailed). c In vitro and in vivo correlation of mannitol and sucrose based on the permeability coefficientsBack to article page