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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

Fig. 5

a Permeability coefficient (P) of mannitol and sucrose in the Transwell model with TEER value of 1812 ± 54 Ω cm2 (n = 3). b Permeability coefficient (P) of mannitol and sucrose in the vivo model (n = 6). ****p < 0.0001, analyzed by Student’s unpaired t-test (two-tailed). c In vitro and in vivo correlation of mannitol and sucrose based on the permeability coefficients

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Fluids and Barriers of the CNS

ISSN: 2045-8118