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Table 3 Comparison of questionnaire data between the probable fNPH patients (n = 60) vs. their ≥ 60-year-old non-iNPH relatives (n = 49), from a total of 39 different families

From: Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case–control comparison with family members

  Probable fNPH patients (n = 60) Non-iNPH relatives, age ≥ 60 (n = 49) p-value
Mean age at questionnaire (± SD) 76.9 (± 7.4) 70.0 (± 8.4) <0.001a
Sex (F/M) 32/28 (53.3%) 28/21 (57.1%) 0.704b
Mean BMI (± SD) 27.8 (± 4.4) 27.5 (± 5.3) 0.501a
Smoking and alcohol
 Smoker or ex-smoker 16/60 (26.7%) 18/49 (36.7%) 0.302b
 Consumes alcohol 19/60 (31.7%) 31/49 (63.3%) 0.001b
Prevalence of
 APOE ε4 10/45 (22.2%) 8/25 (32.0%) 0.403b
 Loss of CN in intron 2 of SFMBT1 4/44 (9.1%) 2/22 (9.1%) 1.000b
Memory and neurological comorbidities
 Diagnosed AD 10/60 (16.9%) 2/49 (4.1%) 0.061b
 Parkinsonism 2/60 (3.3%) 0/49 (0.0%) 0.501b
 Other diagnosed neurodegenerative disorder 2/59(3.4%) 1/49 (2.0%) 1.000b
 Epilepsy 5/60 (8.3%) 1/49 (2.0%) 0.220b
Cardiovascular comorbidities
 Arterial hypertension 39/60 (65.0%) 21/49 (42.9%) 0.033b
 Diabetes 19/60 (31.7%) 7/49 (14.3%) 0.043b
 Coronary artery disease 8/58 (13.8%) 2/48 (4.2%) 0.108b
 Myocardial infarction 2/58 (3.4%) 0/49 (0.0%) 0.499b
 Cardiac insufficiency 9/58 (15.5%) 1/49 (2.0%) 0.020b
 Cardiac arrhythmia 13/58 (22.4%) 8/41 (16.3%) 0.473b
 Venous thrombosis 6/59 (10.2%) 2/48 (4.2%) 0.292b
 Stroke/TIA 2/58 (3.4%) 2/49 (4.1%) 1.000b
Other comorbidities
 Rheumatoid arthritis 2/59 (3.4%) 2/47 (4.3%) 1.000b
 Spinal stenosis 11/58 (19.0%) 3/48 (6.3%) 0.082b
 Depressive symptoms 19/59 (32.2%) 4/49 (8.2%) 0.004b
 Other mental disease 4/59 (6.8%) 1/49 (2.0%) 0.374b
 Asthma 11/60 (18.3%) 9/49 (18.4%) 1.000b
 COPD 3/60 (5.0%) 1/49 (2.0%) 0.626b
 Peptic ulcer 4/60 (6.7%) 1/49 (2.0%) 0.376b
Hypothyroidism 7/58 (12.1%) 6/49 (12.2%) 1.000b
 Chronic snoring 12/60 (20.0%) 10/49 (20.4%) 1.000b
 Sleep apnea 3/59 (5.1%) 3/48 (6.3%) 1.000b
 Mean modified CC score (± SD) 0.95 (± 1.06) 0.75 (± 1.12) 0.336a
Performance
 Is able to fill the questionnaire independently 27/59 (45.8%) 43/49 (87.8%) <0.001b
  1. Italic values indicate significance of p value (< 0.05)
  2. The questionnaire included more data but only the more interesting findings are shown in this table
  3. fNPH familial idiopathic normal pressure hydrocephalus, SD standard deviation, F/M female/male, BMI body mass index, AD Alzheimer’s disease, TIA transient ischemic attack, COPD chronic obstructive pulmonary disease, CCI Charlson comorbidity index
  4. aMann-Whitney U test (two-tailed)
  5. bFisher’s exact test (two-tailed)
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