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Table 1 Parameters used in simulations

From: Functional hyperemia drives fluid exchange in the paravascular space

Parameter name Symbol Default Range Unit Source
Arteriolar radius R1 12 5 to 20 µm [49,50,– 51]
PVS length La 250 250 to 500 µm [50, 145]
PVS width wd 3 2–10 µm [16, 42, 43]
CSF viscosity µf 0.001 Pa.s [47, 48]
CSF density ρf 1000 - kg/m3 [47, 48]
PVS porosity ζ 0.8 0.5–0.9 [16, 17, 146]
PVS permeability ks 2 × 10−14 7 × 10−13 to 2 × 10−15 m2 [12, 14, 45, 46]
Brain section radius R3 150 100–200 µm [145, 147]
Brain shear modulus µs 4 1–8 kPa [29,30,31,32, 63,64,65,66]
Brain tissue density ρ1 1000 kg/m3 [148]
Pulsation amplitude (% arteriolar radius) b1 1 0.5–2 [16]
Pulsation frequency f 10 7–14 Hz [72]
Pulse wave speed c 1 0.5–10 m/s [69,70,71]
Pulse wave wavelength λ 0.1 0.03–1.43 m c/f
Diffusion coefficient D 1.4 × 10−6 cm2/s [134, 135]