Fig. 1
From: Functional hyperemia drives fluid exchange in the paravascular space
Schematic of the anatomical structure of a penetrating arteriole and surrounding tissue. a Depiction the fluid filled PVS between the arteriolar wall and the brain parenchyma. adapted from Abbot et al. [10]. The glia limitans covers the surface of the brain tissue and forms the brain-PVS interface. The subarachnoid space (SAS) and paravascular spaces (PVS) are interconnected fluid-filled compartments. The low resistance pathway for fluid flow to and from the PVS (along the SAS) is shown in green, while the high resistance pathway (through the brain parenchyma) is shown in magenta. b Geometry of the computational model of a penetrating arteriole and the brain and fluid around it. The model is cylindrically symmetric around the penetrating arteriole, allowing us to use axisymmetric simulations (see Additional file 1: Appendix for full mathematical detail)