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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Fig. 4

The abundance of RMT receptor and transporter gene transcripts in human (a) and mouse (b) brain microvessels (BMV). BMVs were isolated as described in Materials and Methods and subjected to RNASeq analyses. Data are shown as normalized read counts (Mean ± SD from three biological replicates). Statistical analyses was performed using one-way ANOVA, followed by Tukey’s multiple comparisons test and p < 0.05 was considered significant. For human BMV (a), the level of SLC2A1/GLUT1 is significantly higher than those of IGF2R, LRP8, and LEPR (p < 0.05). The level of SLC3A2/CD98hc is significantly higher than those of LDLR, LRP8, IGFR, IGF2R and LEPR (p < 0.05). The level of LRP1 is significantly higher than those of TFRC, LDLR, IGF1R and LEPR (p < 0.05) and LRP8 and IGF2R (p < 0.01). For mouse BMV (b), the level of SLC2A1/GLUT1 is significantly higher than those of TFRC, INSR, IGF1R, IGF2R, LDLR, LRP8, CDC50A, and LEPR (p < 0.0001), and LRP1 (p < 0.001). The level of SLC3A2/CD98hc is significantly higher than those of TFRC and INSR (p < 0.05), LDLR, IGF2R and LEPR (p < 0.0001). The level of LRP1 is significantly higher than those of TFRC, INSR, IGF2R, LDLR, LRP8 and LEPR (p < 0.0001) and CDC50A (p < 0.001). The level of IGF1R is significantly higher than those of TFRC and INSR (p < 0.01), CDC50A (p < 0.05), IGF2R and LEPR (p < 0.0001). The level of TFRC is significantly higher than those of IGF2R (p < 0.05) and LEPR (p < 0.01). The level of LRP8 is significantly higher than those of IGF2R (p < 0.05) and LEPR (p < 0.01). The level of CDC50A is significantly higher than those of IGF2R and LEPR (p < 0.01)

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