Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Table 9 Top differentially expressed pathways for the comparison of soloculture vs. coculture with human pericytes (CHP) at 24 h

Term	Database	Corrected p-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	0.002
Hemostasis	Reactome	0.002
Cell adhesion molecules (CAMs)	KEGG	0.006
Senescence-associated secretory phenotype (SASP)	Reactome	0.007
TNF signaling pathway	KEGG	0.009
CCKR signaling map	PANTHER	0.009
Cell surface interactions at the vascular wall	Reactome	0.014
Chemokine signaling pathway	KEGG	0.016
Osteoclast differentiation	KEGG	0.022
Signaling by cytosolic FGFR1 fusion mutants	Reactome	0.023
Syndecan interactions	Reactome	0.025
Estrogen signaling pathway	KEGG	0.032
Extracellular matrix organization	Reactome	0.035
Propanoate metabolism	KEGG	0.036
2-Oxobutanoate degradation	BioCyc	0.037
Valine, leucine and isoleucine degradation	KEGG	0.038
Integrin cell surface interactions	Reactome	0.040
Immune system	Reactome	0.047

Pathway analysis was conducted using different databases i.e. KEGG pathway, Reactome and Panther. Statistical analysis was performed using the Fisher’s exact test and false discovery rate correction test was performed by the Benjamini and Hochberg method [3]

ISSN: 2045-8118