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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Fig. 2

a Efflux pump activity measured by the intracellular accumulation of rhodamine 123 (R123) in absence (red) or presence (green, lines) of the inhibitor, elacridar (GF) in solocultured endothelial cells (Solo), or in cocultured endothelial cells with bovine pericytes (CBP) and cocultured endothelial cells with human pericytes (CHP). Data is shown as the mean amount intracellular accumulated R123 with standard deviation (in RFU) (N = 3). b Expression profile of ABC efflux transporters P-gp and BCRP in endothelial cells cocultured with human pericytes (CHP, green) or bovine pericytes (CBP, red). Expression is depicted as relative expression (in %) compared to the expression in solocultured endothelial cells at the corresponding time points

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Fluids and Barriers of the CNS

ISSN: 2045-8118