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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Location matters: highly divergent protein levels in samples from different CNS compartments in a clinical trial of rituximab for progressive MS

Fig. 3

Comparison of proteins detected between lumbar CSF and ventricular CSF, obtained at follow-up (between 12 and 60 months post-surgery). a p-values listed for all detected proteins with 0.05 indicated by red line. b Spearman’s rho showing correlation for all detected proteins with lines starting at zero, indicating positive and negative correlation by right and left, respectively. a, b Circles in orange mark proteins from the immunological panel, and circles in blue mark proteins from the neurological panel. Molecular weights (kDa) shown by numbers within coloured circles. c Spread of proteins between compared compartments based on molecular weight (kDa), where a positive standardized difference indicates higher levels in lumbar CSF samples and a negative standardized difference indicates higher levels in ventricular CSF samples. d Boxplot for spread of spearman’s rho subdivided according to the two protein panels

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