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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Location matters: highly divergent protein levels in samples from different CNS compartments in a clinical trial of rituximab for progressive MS

Fig. 2

Comparison of proteins detected between extracellular fluid (ECF) from brain and ventricular CSF at the time of surgery (a) with p-values listed for all detected proteins and 0.05 indicated by red line. b Spearman’s rho showing correlation for all detected proteins with lines starting at zero, indicating positive and negative correlation by right and left, respectively. a, b Circles in orange mark proteins from the immunological panel, and circles in blue mark proteins from the neurological panel. Molecular weights (kDa) are shown by numbers within coloured circles. c Spread of proteins between compared compartments based on molecular weight (kDa), where a positive standardized difference indicates higher levels in ISS samples from brain and a negative standardized difference indicates higher levels in ventricular CSF samples. d Boxplot for spread of spearman’s rho subdivided according to the two protein panels

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Fluids and Barriers of the CNS

ISSN: 2045-8118