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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure

Fig. 6

Influence of cortisol on drug transport across iPSC-derived BMECs cultured in NVUs. Data were acquired with iPSC-derived BMECs cultured for 2 days prior to measurements. For all experiments, astrocyte culture was initiated on day 1. a When measuring the permeability of any drug, 3 kDa dextran was included such that passive permeability could be simultaneously measured. These data in a represent pooled dextran permeability measurements for loperamide, morphine, and oxycodone with and without cortisol treatment (mean ± S.E.M. from N = 15 biological replicates). Statistical significance was calculated using the student’s unpaired t-test (**p < 0.005). b Permeability of loperamide, morphine, and oxycodone with and without cortisol treatment. Data represent mean ± S.E.M. from N = 5 biological replicates. Statistical significance was calculated using the student’s unpaired t-test (*p < 0.05)

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