Fig. 7
The effects of anesthetic on ICP dynamics: ICP measured in rat receiving hypnorm/midazolam in the experimental phase. a ICP trace of ICP before and after the administration of hypnorm/midazolam using 1 min mean values. The peak at time 0 is most likely due to stress from the s.c. injection. Representative ICP waveforms during the baseline period (b) and 45 min after anesthesia induction, showing raw 1 kHz data (c). d A spectrograph detailing the power spectrum of the ICP waveform at baseline, 45 min and 85 min after anesthetic administration. e A temporal spectrogram heat map detailing the change in spectral power in frequency bins over time. f The effect of hypnorm/midazolam on spectral power in the 0–0.24 Hz frequency bin. Repeated measures ANOVA with post hoc Dunnett’s test for C and D. *** = P < 0.001, **** = P < 0.0001. n = 8 for A, n = 4 for B-D. Data presented as mean ± SEM