Fig. 5

Waveform analysis of ICP measured in freely-moving animals: a ICP waveform features. A representative ICP trace detailing ICP waveforms: also showing a respiratory wave (blue) and a cardiac waveform (red), with a 1 kHz sampling frequency. b A zoomed in 1 kHz ICP trace detailing one respiratory wavelength. c, d Representative ICP waveforms displayed at an illustrative 20 Hz sampling mean for the recovery period (RP) and the physiological period (PP) detailing the waveforms in the light (inactive) and dark phase (active). e, f The ICP waveform amplitude of rats during the light and dark state in the RP and PP showing the increased amplitude in the dark phase of the physiological period. g Spectral analysis of the 1 kHz ICP waveform data in both the light and dark phase during the RP and PP (h). E–F presented as mean ± SEM, g, h presented as mean in 0.03 Hz bins. n = 10. Paired t-tests for E and F, **P < 0.01