Fig. 3

Manipulation of ICP in rodents: a Physiological manipulation with change in ICP relative to jugular vein compression followed by postural changes. The increase in ICP during the jugular vein compression (B) is dependent on the force applied. When the rat was kept with its head up the ICP decreased (C) whereas it increased when it was held in a position with its head down (D). b–d Waveform showing the response in ICP signals to jugular vein compression and response in ICP to different body positions over a period of 15–50 s. The dotted lines represent zero pressure. e–f Weight and ICP of rats during the physiological period. Scatter graphs detailing the association between ICP and weight (e), change in ICP and change in weight (f), and change in ICP and change in age (g). Pearson correlations, where P < 0.05 was considered significant, n = 8