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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states

Fig. 2

Continuous long-term ICP recording in freely moving rats: a The design of the long-term study. The recording period was divided into three periods; recovery period (RP), physiological period (PP) and experimental period (EP). During the RP (day 0–8), the rats were kept single-housed to recover from the surgery. The rats received treatment for 2 days post-surgery (buprenorphine, carprofen, enrofloxacin). When the rats had recovered fully from the surgery, they were co-housed (from approximately day 9). Day 9–26 was considered as the PP, where the rats were not affected by anesthesia or any drugs. During the EP (day 27–50), the anesthetic effect of hypnorm/midazolam was evaluated. b Continuous individual daily mean ICP values for each rat over 50 days (n = 10). The ICP measurements were obtained immediately after implantation of the telemetric device on day 0 and continued for up until day 50. c Combined daily mean ICP values during RP, PP and EP. d Mean ICP values obtained from RP going into the PP (up to 9 days). e Repeated measured mixed effects analysis followed by post hoc Tukeys tests for ICP values in the RP, PP and EP. c, d, e Data is presented as mean ± SEM. ** = P<0.01

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