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Table 4 Table summarizing changes of the CP in tumors, schizophrenia and chronic stress

From: Choroid plexus and the blood–cerebrospinal fluid barrier in disease

CategoryDisorderChoroidal epithelial cellsImmune cellsTransportersOthers
TumorsCP papilloma↑ c-Myc expression in CP epithelium
[287]
↑ CD3+ T-lymphocytes, predominantly CD4+ T-helper and CD68+ macrophages
[287]
 Expression of S-100, cytokeratin, vimentin and TTR
[276, 277]
   Villous hypertrophy and diffuse enlargement of the CP
[278]
  ↑ Expression of AQP1
[280]
↑ CP surface
[282]
   ↑ TWIST1 expression
[284]
CP carcinoma   ↑ Ki67 proliferative indices
[275]
   ↑ Myc expression
[286]
   Hypermethylation in the promoter region of AK1, PER2, PLSCR4
[279]
CP cyst   ↑ Water-filled vesicles number
[283]
Primary CP tumors   Expression of cytokeratin AE1/AE3, E-cadherin, N-cadherin, β-catenin, GFAP
[288,289,290]
Schizophrenia↑ Expression of genes related to immune function and inflammation associated with the disease status
[296]
  ↑ CP volume
[297]
Chorionic Stress↓ 5HT2C, glucocorticoid receptor, cilia genes IFT88 expression
↑ 5HT2A, BDNF, TNFα, IL-1β expression
[298]