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Table 4 Table summarizing changes of the CP in tumors, schizophrenia and chronic stress

From: Choroid plexus and the blood–cerebrospinal fluid barrier in disease

CategoryDisorderChoroidal epithelial cellsImmune cellsTransportersOthers
TumorsCP papilloma↑ c-Myc expression in CP epithelium
↑ CD3+ T-lymphocytes, predominantly CD4+ T-helper and CD68+ macrophages
 Expression of S-100, cytokeratin, vimentin and TTR
[276, 277]
   Villous hypertrophy and diffuse enlargement of the CP
  ↑ Expression of AQP1
↑ CP surface
   ↑ TWIST1 expression
CP carcinoma   ↑ Ki67 proliferative indices
   ↑ Myc expression
   Hypermethylation in the promoter region of AK1, PER2, PLSCR4
CP cyst   ↑ Water-filled vesicles number
Primary CP tumors   Expression of cytokeratin AE1/AE3, E-cadherin, N-cadherin, β-catenin, GFAP
Schizophrenia↑ Expression of genes related to immune function and inflammation associated with the disease status
  ↑ CP volume
Chorionic Stress↓ 5HT2C, glucocorticoid receptor, cilia genes IFT88 expression
↑ 5HT2A, BDNF, TNFα, IL-1β expression