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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

Fig. 5

Comparison of TJ and ABC gene expression levels across different species. a mRNA expression levels of OCLN, CLDN1, CLDN5, TJP1 and F11R, and b mRNA expression levels of ABCB1, ABCC1, ABCC4 and ABCG2 in murine, human and bovine brain capillary endothelial cells and in endothelial cells cultured in contact co-culture (CCC) configuration with astrocytes. Transcriptomic data for murine brain capillary endothelial cells (mcapEC) is derived from transcriptomic databases from the Betsholtz lab (Bz) (http://betsholtzlab.org/VascularSingleCells/database.html) and the Barres lab (http://www.brainrnaseq.org/). Data for human brain capillary endothelial cells (hcapEC) are from the Barres lab et al. (Br). All data were normalized against endothelial HPRT-1, GAPDH and β-actin expression in the relative databases. Data are shown as mean values. Human data from Barres database: n = 2. Murine data from Barres database: n = 2. Murine data from Betsholtz database: n = 2. Bovine data: n = 3, N = 3

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Fluids and Barriers of the CNS

ISSN: 2045-8118