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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

Fig. 3

Efflux transporters. a Quantitative mRNA expression levels of ABCB1. The expression levels were significantly decreased from capillaries to all culture configurations. b Quantitative mRNA expression levels of ABCG2. There were no significant differences in expression levels of ABCG2. c Quantitative mRNA expression levels of ABCC1. The expression of ABCC1 was significantly increased from capillaries to all culture configurations. There was a significant increase in the expression in CCC compared to MC. d mRNA expression levels of ABCC4. There were no significant differences in expression levels, although a non-specific increase was observed from capillaries to all culture configurations. ABCB1: Pgp, ABCG2: BCRP, ABCC1: MRP-1, ABCC4: MRP-4. MC: Mono culture, NCC: Non-contact co-culture, CCC: Contact co-culture. n = 3, N = 3. *: P ≤ 0.5. Error bars are mean + SEM

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