Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model

Table 2 Correlation analysis of chemokine concentrations and tumour characteristics

Correlates with:		MCP-1 (pg/ml)	RANTES (pg/ml)	SDF-1a/b (pg/ml)	BCA-1 (pg/ml)	CCL20 (pg/ml)	Grading	Ki67 staining
Fractalkine (pg/ml)	r	− 0.03	0.09	0.18	0.19	0.04	0.13	0.18
Fractalkine (pg/ml)	p	0.83	0.45	0.12	0.11	0.73	0.33	0.20
MCP-1 (pg/ml)	r		0.238*	0.13	− 0.12	0.00	− 0.04	0.02
MCP-1 (pg/ml)	p		0.04	0.26	0.29	0.99	0.79	0.87
RANTES (pg/ml)	r			0.20	0.04	0.05	− 0.09	0.19
RANTES (pg/ml)	p			0.05	0.68	0.60	0.44	0.11
SDF-1a/b (pg/ml)	r				0.02	− 0.12	− 0.09	0.17
SDF-1a/b (pg/ml)	p				0.83	0.24	0.41	0.15
BCA-1 (pg/ml)	r					0.362**	− 0.04	0.08
BCA-1 (pg/ml)	p					< 0.01	0.72	0.51
CCL20 (pg/ml)	r						0.00	0.15
CCL20 (pg/ml)	p						0.98	0.24
Grading	r							0.456**
Grading	p							< 0.01

r correlation coefficient (the positive “r” means positive correlation, while the negative “r” means negative correlation; the closer r value to 1 or − 1, the greater the correlation)
p: p value indicating statistical significance
*p < 0.05; **p < 0.01

ISSN: 2045-8118