Table 1 Model 1 default parameters (corresponding to full model) cf. Fig. 1 and Eqs. (1), (2)
From: Intracranial pressure elevation alters CSF clearance pathways
| Parameter | Symbol | Value | Unit | References |
|---|---|---|---|---|
| Dural sinus pressure | \(p_{{\text {d}}}\) | 8.4 | mmHg | Eq. (17 ) [61,62,63] |
| Cervical lymph pressure | \(p_{{\text {crib}}}\) | 0 | mmHg | [64] |
| Pial sleeves pressure | \(p_{{\text {V}}}\) | 8.4 | mmHg | Model assumption |
| Hydrostatic capillary pressure | \(p_{cap,h}\) | 35 | mmHg | [73] |
| Effective capillary pressure | \(p_{\mathrm{cap}}\) | 20 | mmHg | Eq. (19) |
| Reference pressure | \(p_{{\text {r}}}\) | 9 | mmHg | [39] |
| Threshold pressure | \(p_{{\text {thres}}}\) | 11 | mmHg | [34] |
| AGs resistance | \(R_{{\text {AG}}}\) | 10.81 | mmHg/(mL/min) | [57] |
| Paraarterial resistance | \(R_{{\text {aPVS}}}\) | 1.14 | mmHg/(mL/min) | [11] |
| Arterial IEG resistance | \(R_{\mathrm{IEG,a}}\) | 0.57 | mmHg/(mL/min) | Eq. (15) [50] |
| Venous IEG resistance | \(R_{\mathrm{IEG,v}}\) | 0.64 | mmHg/(mL/min) | Eq. (15) [50] |
| ECS resistance | \(R_{\mathrm{ECS}}\) | 0.57 | mmHg/(mL/min) | Eqs. (12, 13) [14, 49] |
| Capillary gaps resistance | \(R_{{\text {gaps}}}\) | 32.24 | mmHg/(mL/min) | Eq. (8) [45] |
| Paravenous resistance | \(R_{{\text {v}}}\) | \(1.75 \times 10^{-3}\) | mmHg/(mL/min) | [11] |
| Lumped model resistance | \(R_{{\text {V}}}\) | 1.69 | mmHg/(mL/min) | Eq. (3) |
| Cribriform plate resistance | \(R_{{\text {crib}}}\) | 67 | mmHg/(mL/min) | Eq. (3) |
| Capillary wall resistance | \(R_{{\text {cap}}}\) | 125.31 | mmHg/(mL/min) | Eq. (16) |
| Subarachnoid space elastance | E | 0.2 | \({\text {mL}}^{-1}\) | [27] |
| CSF production rate | \(Q_{{\text {prod}}}\) | 0.33 | mL/min | [40,41,42,43] |
| Infusion rate | \(Q_{{\text {inf}}}\) | 1.5 | mL/min | [27] |