Table 1 Model 1 default parameters (corresponding to full model) cf. Fig. 1 and Eqs. (1), (2)

Dural sinus pressure

\(p_{{\text {d}}}\)

8.4

mmHg

Eq. (17 ) [61,62,63]

Cervical lymph pressure

\(p_{{\text {crib}}}\)

0

mmHg

[64]

Pial sleeves pressure

\(p_{{\text {V}}}\)

8.4

mmHg

Model assumption

Hydrostatic capillary pressure

\(p_{cap,h}\)

35

mmHg

[73]

Effective capillary pressure

\(p_{\mathrm{cap}}\)

20

mmHg

Eq. (19)

Reference pressure

\(p_{{\text {r}}}\)

9

mmHg

[39]

Threshold pressure

\(p_{{\text {thres}}}\)

11

mmHg

[34]

AGs resistance

\(R_{{\text {AG}}}\)

10.81

mmHg/(mL/min)

[57]

Paraarterial resistance

\(R_{{\text {aPVS}}}\)

1.14

mmHg/(mL/min)

[11]

Arterial IEG resistance

\(R_{\mathrm{IEG,a}}\)

0.57

mmHg/(mL/min)

Eq. (15) [50]

Venous IEG resistance

\(R_{\mathrm{IEG,v}}\)

0.64

mmHg/(mL/min)

Eq. (15) [50]

ECS resistance

\(R_{\mathrm{ECS}}\)

0.57

mmHg/(mL/min)

Eqs.  (12, 13) [14, 49]

Capillary gaps resistance

\(R_{{\text {gaps}}}\)

32.24

mmHg/(mL/min)

Eq. (8) [45]

Paravenous resistance

\(R_{{\text {v}}}\)

\(1.75 \times 10^{-3}\)

mmHg/(mL/min)

[11]

Lumped model resistance

\(R_{{\text {V}}}\)

1.69

mmHg/(mL/min)

Eq. (3)

Cribriform plate resistance

\(R_{{\text {crib}}}\)

67

mmHg/(mL/min)

Eq. (3)

Capillary wall resistance

\(R_{{\text {cap}}}\)

125.31

mmHg/(mL/min)

Eq. (16)

Subarachnoid space elastance

E

0.2

\({\text {mL}}^{-1}\)

[27]

CSF production rate

\(Q_{{\text {prod}}}\)

0.33

mL/min

[40,41,42,43]

Infusion rate

\(Q_{{\text {inf}}}\)

1.5

mL/min

[27]