Fig. 2

Reference model. An established model for analysis of clinical infusion tests, in which CSF flows out through the arachnoid granulations, with the dural sinus as the outflow compartment and \(p_{\text {out}} = p_{\text {d}}\). The intracranial resting pressure (\({\text {ICP}}_r\)) is assumed to be related to the unknown \(p_{{\text {out}}}\), \(Q_{{\text {prod}}}\), and \(R_{\text {out}}\) by \(p_{\text {out}} = {\text {ICP}}_r - Q_{{\text {prod}}} R_{\text {out}}\)