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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Angiomodulin (IGFBP7) is a cerebral specific angiocrine factor, but is probably not a blood–brain barrier inducer

Fig. 4

Angiomodulin protein expression in adult mouse brain is not restricted to the vasculature. a AGM (green) is expressed in adult CNS vasculature (examples of representative cortical sections form two adult mice). Different from the embryonic situation, in addition to vasculature staining (arrows, co-labeled with CD31 positive endothelium (red)), we also detected cellular staining in CNS parenchyma (arrow heads). Merge images includes DAPI nuclei staining. N = 3 mice; scale bar 100 µm. b AGM staining in CNS parenchyma includes co-localization with a subset of microglia cells (labeled with CD45, arrows upper panel), co-localization with a subset of astrocytes (labeled with S100-beta, arrows middle panel) and co-localization with a subset of neurons (labeled with NeuN, arrows lower panel). Scale bar 50 µm

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Fluids and Barriers of the CNS

ISSN: 2045-8118