Skip to main content
Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Angiomodulin (IGFBP7) is a cerebral specific angiocrine factor, but is probably not a blood–brain barrier inducer

Fig. 2

Angiomodulin protein expression is specific to developing cerebral vasculature and not to highly angiogenic developing vasculature of peripheral organs. a AGM (green) could be detected as early as E12.5 in cortical vasculature (upper panel, arrow heads), co-labeled with CD31 positive endothelium (red). AGM expression was specific to CNS vasculature, as it was not detected in developing peripheral organs such as the heart or liver (middle and lower panels). Merge images includes DAPI nuclei staining. N = 3 mice; scale bar 100 µm for two upper panels and 200 µm for the lower panel. b AGM (green) co-localizes with CD31 positive endothelial cells (red, arrows) and PDGFR-beta pericytes (blue, arrow heads) shown in high magnification confocal imaging of E14.5 cortical vasculature. Scale bar 25 µm

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118