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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: In vitro modeling of the neurovascular unit: advances in the field

Fig. 3

Schematic representation of a 3D ECM-based in vitro BBB model. This platform enables culturing multiple cell types (related to a specific organ system) at once. The formation of natural gradients of biological factors (either introduced into the matrix and/or naturally produced by the cells in culture) promotes a host of physiological responses (including cell migration, interaction, and differentiation) culminating with the self-assembly of microvascular processes and the formation of a network of capillary-like structures in vitro

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