Table 2 Comparison of claudin expression data in brain endothelial cells or capillaries derived from the present work (hCMEC/D3), from Berndt et al. [3] (laser-microdissected human brain capillaries), the Barres¹ (isolated brain endothelial cells) and the Betsholtz data base² (single cell sequences brain capillary endothelial cells—capEC)

Cldn1

1000

2

30

4

0.2

7

nd

–

Cldn2

nd

–

1.26

15

0.1

11

3

4

Cldn3

5.2

20

6.08

9

0.3

5

0.05

9

Cldn4

18

16

4.43

11

0.1

11

nd

–

Cldn5

39

9

205

1

< 3500

1

1500

1

Cldn6

18

15

7.51

7

2

3

0.1

7

Cldn7

219

5

nd

–

0.12

9

nd

–

Cldn8

18

14

nd

–

0.1

11

nd

–

Cldn9

25

12

13.4

5

0.15

8

nd

–

Cldn10

142, 116

6^a

nd

–

nd

–

nd

–

Cldn11

3189

1

162

2

nd

–

nd

–

Cldn12

281, 18, 291

3, 4, 13^b

114

3

5

2

20

3

Cldn13

#

–

#

–

0.1

11

nd

–

Cldn14

69

7

nd

–

nd

–

nd

–

Cldn15

17

17

6.13

8

0.4

4

nd

–

Cldn16

8

19

nd

–

0.1

11

0.02

10

Cldn17

30

10

5.85

10

0.1

11

nd

–

Cldn18

27, 3.71

11, 22^c

nd

–

0.1

11

0.1

7

Cldn19

nd

–

nd

–

0.1

11

< 0.1

11

Cldn20

52

8

3.35

13

0.1

11

0.4

5

Cldn21

nd

–

nd

–

##

–

##

–

Cldn22

9.97

18

3.95

12

0.3

5

0.2

6

Cldn23

0.25

24

1.59

14

0.1

11

nd

–

Cldn24

3.65

23

nd

–

0.12

9

na

–

Cldn25

4.77

21

nd

–

na

–

30

2