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Table 2 Comparison of claudin expression data in brain endothelial cells or capillaries derived from the present work (hCMEC/D3), from Berndt et al. [3] (laser-microdissected human brain capillaries), the Barres1 (isolated brain endothelial cells) and the Betsholtz data base2 (single cell sequences brain capillary endothelial cells—capEC)

From: The pivotal role of micro-environmental cells in a human blood–brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis

SpeciesCurrent work qPCR3RankBerndt et al. [3]
qPCR4
RankBarres data base (FPKM)RankBetsholtz data base (counts)Rank
HumanHumanMouseMouse
Cldn1100023040.27nd
Cldn2nd1.26150.11134
Cldn35.2206.0890.350.059
Cldn418164.43110.111nd
Cldn53992051< 3500115001
Cldn618157.517230.17
Cldn72195nd0.129nd
Cldn81814nd0.111nd
Cldn9251213.450.158nd
Cldn10142, 1166andndnd
Cldn11318911622ndnd
Cldn12281, 18, 2913, 4, 13b114352203
Cldn13##0.111nd
Cldn14697ndndnd
Cldn1517176.1380.44nd
Cldn16819nd0.1110.0210
Cldn1730105.85100.111nd
Cldn1827, 3.7111, 22cnd0.1110.17
Cldn19ndnd0.111< 0.111
Cldn205283.35130.1110.45
Cldn21ndnd####
Cldn229.97183.95120.350.26
Cldn230.25241.59140.111nd
Cldn243.6523nd0.129na
Cldn254.7721ndna302
  1. nd = not detected; CLDN21 = CLDN22 at human; na = not available; #: not encoded in human; ##: not encoded in mouse; adata listed are for Cldn10 tva and tvb; bdata listed are for Cldn12 tv1, tv2, tv3; cdata listed are for Cldn18 tv1b and tv2a.; 1Zhang et al. [54], accessed on 21st of January 2020: https://web.stanford.edu/group/barres_lab/brain_rnaseq.html; 2Vanlandewijck et al. [46], He et al. [16], accessed on 21st of January 2020: http://betsholtzlab.org/VascularSingleCells/database.html; 3mean values related to Cldn1, which was set to 1000; 4mean values * 10−4 from the supplementary file of Berndt et al. [3]