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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: The pivotal role of micro-environmental cells in a human blood–brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis

Fig. 4

Addition of glioma C6 cells increased the damage of the paracellular barrier of hCMEC/D3 layers after 5 h OGD treatment at 1% O2. a TEER change is normalized to the TEER progression of the normoxia control. b Permeability of FITC-dextran 4000 (n = 9–12 inserts from three independent experiments). Data are presented as mean ± SEM. *Statistical significant versus normoxia hCMEC/D3, p < 0.05, #statistical significant versus OGD hCMEC/D3 + C6, p < 0.05; §statistical significant versus normoxia hCMEC/D3, p < 0.05. Two-Way ANOVA with all pairwise multiple comparison Holm-Sidak in case of non-normality distribution or non-equal variances

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Fluids and Barriers of the CNS

ISSN: 2045-8118