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Table 1 Comparison of intracranial and extracranial flow parameters in younger and older healthy adults

From: Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study

Parameters

Healthy young volunteers

mean ± SD (max–min)

Healthy elderly volunteers

mean ± SD (max–min)

p-values

n

16

19

 

Age

31 ± 7 (26–44)

73 ± 6 (63–82)

***

ExtraACBF (ml/min)

716 ± 129 (531–933)

588 ± 119 (396–771)

0.007**

IntraACBF (ml/min)

670 ± 158 (329–951)

593 ± 107 (343–753)

0.12ns

p-values

0.4ns

0.7ns

 

Mean Total Arterial Cerebral Blood Flow (ml/min)

693 ± 117 (433–899)

591 ± 102 (370–740)

0.006**

ExtraVCBF (ml/min)

449 ± 173 (250–778)

533 ± 161 (171–707)

0.09ns

IntraVCBF (ml/min)

478 ± 94 (365–682)

379 ± 88 (171–501)

0.01*

p-values

0.66ns

0.0002***

 

αExtra

1.67 ± 0.75 (0.95–3.71)

1.24 ± 0.52 (0.65–2.44)

0.01*

αIntra

1.52 ± 0.34 (0.99–2.38)

1.59 ± 0.41 (0.99–2.64)

0.81ns

p-values

0.68ns

0.038*

 

Extra blood SV (ml/cc)

0.91 ± 0.39 (0.49–2.08)

0.98 ± 0.32 (0.48–1.61)

0.24ns

Intra blood SV (ml/cc)

0.76 ± 0.30 (0.29–1.28)

1.08 ± 0.21 (0.53–1.57)

0.001**

p-values

0.21ns

0.31ns

 

Spinal CSF SV (ml/cc)

0.34 ± 0.21 (0.08–0.86)

0.51 ± 0.20 (0.16–0.89)

0.02*

Aqueductal CSF SV (ml/cc)

0.04 ± 0.02 (0.01–0.08)

0.05 ± 0.03 (0.01–0.10)

0.26ns

Extra arterial PI

0.85 ± 0.17 (0.45–1.11)

1.31 ± 0.32 (1.01–2.05)

4.78 × 10–8***

Intra arterial PI

0.77 ± 0.22 (0.30–1.04)

1.16 ± 0.17 (0.86–1.55)

2.50 × 10–7***

p-values

0.06ns

0.003**

 

Intra Venous PI

0.25 ± 0.16 (0.03–0.70)

0.52 ± 0.16 (0.34–0.97)

3.54 × 10–6***

Extra Venous PI

0.47 ± 0.25 (0.14–0.91)

0.86 ± 0.40 (0.34–1.89)

0.002***

p-values

0.001 **

0.0002***

 

Heart rate (beats/min)

69 ± 14 (47–95)

70 ± 11 (60–100)

0.72ns

  1. In brackets are the maximal (max) − minimal (min) values. Values in italics cells are the p-values for the comparisons between extracranial and intracranial levels for each group. Those in underlined are the p-values for the comparison between HYV and HEV. *p < 0.05; **p < 0.01; ***p < 0.001
  2. ns non-significant, ACBF arterial cerebral blood flow, VCBF venous cerebral blood flow, SV stroke volume, PI pulsatility index