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Light microscopy immunohistochemistry
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Mitochondria in astrocytic endfoot processes
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|---|
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Number of normal mitochondria
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Number of pathological mitochondria
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|---|
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AQP4-perivascular (AU)
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R = − 0.61, P < 0.001
|
R = 0.44, P = 0.019
|
|
AQP4-neuropil (AU)
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R = − 0.22 (ns)
|
R = 0.43, P = 0.024
|
|
Dp71-perivascular (AU)
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R = − 0.65, P < 0.001
|
R = 0.64, P < 0.001
|
|
Dp71-neuropil (AU)
|
R = − 0.09 (ns)
|
R = 0.24 (ns)
|
|
CD68 neuropil (% area)
|
R = − 0.36, P = 0.056
|
R = 0.19 (ns)
|
- R = Pearson correlations. It should be noted that reduced arbitrary units (AU) is indicative of increased AQP4 expression because higher AQP4 causes less transmission of light and thereby reduction of AUs. On the other hand, increased AU means that more light is transferred because of reduced AQP4 expression. Ns = non-significant
