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Table 4 Association between number of normal and pathological mitochondria in astrocytic endfoot processes and light microscopy findings of the REF (n = 9) and iNPH (N = 30) cohorts

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

Light microscopy immunohistochemistry

Mitochondria in astrocytic endfoot processes

Number of normal mitochondria

Number of pathological mitochondria

AQP4-perivascular (AU)

R = − 0.61, P < 0.001

R = 0.44, P = 0.019

AQP4-neuropil (AU)

R = − 0.22 (ns)

R = 0.43, P = 0.024

Dp71-perivascular (AU)

R = − 0.65, P < 0.001

R = 0.64, P < 0.001

Dp71-neuropil (AU)

R = − 0.09 (ns)

R = 0.24 (ns)

CD68 neuropil (% area)

R = − 0.36, P = 0.056

R = 0.19 (ns)

  1. R = Pearson correlations. It should be noted that reduced arbitrary units (AU) is indicative of increased AQP4 expression because higher AQP4 causes less transmission of light and thereby reduction of AUs. On the other hand, increased AU means that more light is transferred because of reduced AQP4 expression. Ns = non-significant
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Fluids and Barriers of the CNS

ISSN: 2045-8118