Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

Table 4 Association between number of normal and pathological mitochondria in astrocytic endfoot processes and light microscopy findings of the REF (n = 9) and iNPH (N = 30) cohorts

Light microscopy immunohistochemistry	Mitochondria in astrocytic endfoot processes
Light microscopy immunohistochemistry	Number of normal mitochondria	Number of pathological mitochondria
AQP4-perivascular (AU)	R = − 0.61, P < 0.001	R = 0.44, P = 0.019
AQP4-neuropil (AU)	R = − 0.22 (ns)	R = 0.43, P = 0.024
Dp71-perivascular (AU)	R = − 0.65, P < 0.001	R = 0.64, P < 0.001
Dp71-neuropil (AU)	R = − 0.09 (ns)	R = 0.24 (ns)
CD68 neuropil (% area)	R = − 0.36, P = 0.056	R = 0.19 (ns)

R = Pearson correlations. It should be noted that reduced arbitrary units (AU) is indicative of increased AQP4 expression because higher AQP4 causes less transmission of light and thereby reduction of AUs. On the other hand, increased AU means that more light is transferred because of reduced AQP4 expression. Ns = non-significant