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Table 3 Normal and pathological mitochondria in astrocytic endfoot processes of REF and iNPH subjects

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

  REF iNPH Significance
Normal mitochondria
 Number of normal mitochondria per astrocytic endfoot process (N) 18.4 ± 9.4 2.6 ± 3.6 P < 0.001
 Area of normal mitochondria per endfoot processes (nm2) 132,672 ± 48,823 81,923 ± 82,860 ns
 Fraction of normal mitochondria per endfoot process (%) 7.2 ± 3.0 5.3 ± 5.6 ns
Pathological mitochondria
 Number of pathological mitochondria per astrocytic endfoot process (N) 0.4 ± 0.8 3.8 ± 2.5 P = 0.003
 Area of pathological mitochondria per endfoot processes (nm2) 28,903 ± 49,387 146,356 ± 86,682 P = 0.03
 Fraction of pathological mitochondria per endfoot process (%) 1.8 ± 3.1 10.8 ± 8.4 ns
  1. Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis
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Fluids and Barriers of the CNS

ISSN: 2045-8118