Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

Table 3 Normal and pathological mitochondria in astrocytic endfoot processes of REF and iNPH subjects

	REF	iNPH	Significance
Normal mitochondria
Number of normal mitochondria per astrocytic endfoot process (N)	18.4 ± 9.4	2.6 ± 3.6	P < 0.001
Area of normal mitochondria per endfoot processes (nm²)	132,672 ± 48,823	81,923 ± 82,860	ns
Fraction of normal mitochondria per endfoot process (%)	7.2 ± 3.0	5.3 ± 5.6	ns
Pathological mitochondria
Number of pathological mitochondria per astrocytic endfoot process (N)	0.4 ± 0.8	3.8 ± 2.5	P = 0.003
Area of pathological mitochondria per endfoot processes (nm²)	28,903 ± 49,387	146,356 ± 86,682	P = 0.03
Fraction of pathological mitochondria per endfoot process (%)	1.8 ± 3.1	10.8 ± 8.4	ns

Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis