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Table 3 Normal and pathological mitochondria in astrocytic endfoot processes of REF and iNPH subjects

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

 

REF

iNPH

Significance

Normal mitochondria

 Number of normal mitochondria per astrocytic endfoot process (N)

18.4 ± 9.4

2.6 ± 3.6

P < 0.001

 Area of normal mitochondria per endfoot processes (nm2)

132,672 ± 48,823

81,923 ± 82,860

ns

 Fraction of normal mitochondria per endfoot process (%)

7.2 ± 3.0

5.3 ± 5.6

ns

Pathological mitochondria

 Number of pathological mitochondria per astrocytic endfoot process (N)

0.4 ± 0.8

3.8 ± 2.5

P = 0.003

 Area of pathological mitochondria per endfoot processes (nm2)

28,903 ± 49,387

146,356 ± 86,682

P = 0.03

 Fraction of pathological mitochondria per endfoot process (%)

1.8 ± 3.1

10.8 ± 8.4

ns

  1. Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis
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Fluids and Barriers of the CNS

ISSN: 2045-8118