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Table 2 Normal and pathological mitochondria in pre- and postsynaptic terminals of REF and iNPH subjects

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

  REF iNPH Significance
Presynaptic terminals
 Normal mitochondria
  Number of normal mitochondria per presynaptic terminal (N) 25.6 ± 16.1 11.3 ± 5.3 ns
  Area of normal mitochondria per presynaptic terminal (nm2) 91,017 ± 32,840 108,668 ± 81,513 ns
  Fraction of normal mitochondria per presynaptic terminal (%) 11.9 ± 4.7 13.5 ± 9.6 ns
 Pathological mitochondria    
  Number of pathological mitochondria per presynaptic terminal (N) 0.1 ± 0.3 4.9 ± 4.2 P = 0.05
  Area of pathological mitochondria per presynaptic terminal (nm2) 59,537 ± 178,611 152,763 ± 149,111 ns
  Fraction of pathological mitochondria per presynaptic terminal (%) 7.2 ± 21.5 15.7 ± 6.4 ns
Postsynaptic terminals
 Normal mitochondria
  Number of normal mitochondria per postsynaptic terminal (N) 6.1 ± 5.6 2.9 ± 2.7 ns
  Area of normal mitochondria per postsynaptic terminal (nm2) 160,597 ± 83,189 101,246 ± 83,823 P = 0.02
  Fraction of normal mitochondria per postsynaptic terminal (%) 26.8 ± 15.1 15.2 ± 12.4 ns
 Pathological mitochondria
  Number of pathological mitochondria per postsynaptic terminal (N) 0 3.1 ± 2.7 P = 0.02
  Area of pathological mitochondria per postsynaptic terminal (nm2) 0 158,834 ± 109,688 P = 0.03
  Fraction of pathological mitochondria per postsynaptic terminal (%) 0 33.0 ± 20.4 P = 0.02
  1. Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis