Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

Table 2 Normal and pathological mitochondria in pre- and postsynaptic terminals of REF and iNPH subjects

	REF	iNPH	Significance
Presynaptic terminals
Normal mitochondria
Number of normal mitochondria per presynaptic terminal (N)	25.6 ± 16.1	11.3 ± 5.3	ns
Area of normal mitochondria per presynaptic terminal (nm²)	91,017 ± 32,840	108,668 ± 81,513	ns
Fraction of normal mitochondria per presynaptic terminal (%)	11.9 ± 4.7	13.5 ± 9.6	ns
Pathological mitochondria
Number of pathological mitochondria per presynaptic terminal (N)	0.1 ± 0.3	4.9 ± 4.2	P = 0.05
Area of pathological mitochondria per presynaptic terminal (nm²)	59,537 ± 178,611	152,763 ± 149,111	ns
Fraction of pathological mitochondria per presynaptic terminal (%)	7.2 ± 21.5	15.7 ± 6.4	ns
Postsynaptic terminals
Normal mitochondria
Number of normal mitochondria per postsynaptic terminal (N)	6.1 ± 5.6	2.9 ± 2.7	ns
Area of normal mitochondria per postsynaptic terminal (nm²)	160,597 ± 83,189	101,246 ± 83,823	P = 0.02
Fraction of normal mitochondria per postsynaptic terminal (%)	26.8 ± 15.1	15.2 ± 12.4	ns
Pathological mitochondria
Number of pathological mitochondria per postsynaptic terminal (N)	0	3.1 ± 2.7	P = 0.02
Area of pathological mitochondria per postsynaptic terminal (nm²)	0	158,834 ± 109,688	P = 0.03
Fraction of pathological mitochondria per postsynaptic terminal (%)	0	33.0 ± 20.4	P = 0.02

Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis