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Table 2 Normal and pathological mitochondria in pre- and postsynaptic terminals of REF and iNPH subjects

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

 REFiNPHSignificance
Presynaptic terminals
 Normal mitochondria
  Number of normal mitochondria per presynaptic terminal (N)25.6 ± 16.111.3 ± 5.3ns
  Area of normal mitochondria per presynaptic terminal (nm2)91,017 ± 32,840108,668 ± 81,513ns
  Fraction of normal mitochondria per presynaptic terminal (%)11.9 ± 4.713.5 ± 9.6ns
 Pathological mitochondria   
  Number of pathological mitochondria per presynaptic terminal (N)0.1 ± 0.34.9 ± 4.2P = 0.05
  Area of pathological mitochondria per presynaptic terminal (nm2)59,537 ± 178,611152,763 ± 149,111ns
  Fraction of pathological mitochondria per presynaptic terminal (%)7.2 ± 21.515.7 ± 6.4ns
Postsynaptic terminals
 Normal mitochondria
  Number of normal mitochondria per postsynaptic terminal (N)6.1 ± 5.62.9 ± 2.7ns
  Area of normal mitochondria per postsynaptic terminal (nm2)160,597 ± 83,189101,246 ± 83,823P = 0.02
  Fraction of normal mitochondria per postsynaptic terminal (%)26.8 ± 15.115.2 ± 12.4ns
 Pathological mitochondria
  Number of pathological mitochondria per postsynaptic terminal (N)03.1 ± 2.7P = 0.02
  Area of pathological mitochondria per postsynaptic terminal (nm2)0158,834 ± 109,688P = 0.03
  Fraction of pathological mitochondria per postsynaptic terminal (%)033.0 ± 20.4P = 0.02
  1. Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis