Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

Table 1 Normal, pathological and clustered mitochondria in neuronal soma of REF and iNPH subjects

	REF	iNPH	Significance
Normal mitochondria
Number of normal mitochondria per soma (N)	50.8 ± 31.2	36.8 ± 27.6	ns
Area of normal mitochondria per soma (nm²)	134,348 ± 28,130	122,202 ± 71,967	ns
Fraction of normal mitochondria per soma (%)	0.9 ± 0.3	0.6 ± 0.3	P = 0.014
Pathological mitochondria
Number of pathological mitochondria per soma (N)	8.8 ± 11.2	50.9 ± 37.5	P = 0.004
Area of pathological mitochondria per soma (nm²)	240,857 ± 85,877	191,807 ± 77,411	ns
Fraction of pathological mitochondria per soma (%)	0.86 ± 0.73	0.94 ± 0.49	ns
Clustered mitochondria
Number of clustered mitochondria per soma (N)	0.6 ± 1.3	13.6 ± 12.0	P = 0.007
Area of clustered mitochondria per soma (nm²)	535,546 ± 238.686	977,784 ± 501,167	P = 0.005
Fraction of clustered mitochondria per soma (%)	0.7 ± 1.5	4.7 ± 3.3	P = 0.04

Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis