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Table 1 Normal, pathological and clustered mitochondria in neuronal soma of REF and iNPH subjects

From: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

  REF iNPH Significance
Normal mitochondria
 Number of normal mitochondria per soma (N) 50.8 ± 31.2 36.8 ± 27.6 ns
 Area of normal mitochondria per soma (nm2) 134,348 ± 28,130 122,202 ± 71,967 ns
 Fraction of normal mitochondria per soma (%) 0.9 ± 0.3 0.6 ± 0.3 P = 0.014
Pathological mitochondria
 Number of pathological mitochondria per soma (N) 8.8 ± 11.2 50.9 ± 37.5 P = 0.004
 Area of pathological mitochondria per soma (nm2) 240,857 ± 85,877 191,807 ± 77,411 ns
 Fraction of pathological mitochondria per soma (%) 0.86 ± 0.73 0.94 ± 0.49 ns
Clustered mitochondria
 Number of clustered mitochondria per soma (N) 0.6 ± 1.3 13.6 ± 12.0 P = 0.007
 Area of clustered mitochondria per soma (nm2) 535,546 ± 238.686 977,784 ± 501,167 P = 0.005
 Fraction of clustered mitochondria per soma (%) 0.7 ± 1.5 4.7 ± 3.3 P = 0.04
  1. Data presented as mean ± standard deviation (std). Significant differences between continuous variables were determined by multivariate analysis