Fig. 5

Reduced post-synaptic length in iNPH. Post-synaptic density (PSD) length (indicated by white arrow heads) is reduced in iNPH. a Electron microscopy from a REF individual showing presynaptic (Pre) and postsynaptic (Post) terminals, and PSD (black arrowheads). b The PSD in a postsynaptic (Post) terminal of an iNPH patient is indicated by black arrowheads. The PSD was 2.4-fold higher in REF than iNPH individuals (0.61 ± 0.09 µm vs 0.26 ± 0.06 µm (P < 0.001; multivariate analysis). Magnification ×11,500; Scale bar 1 µm. Error bars are 95% CI. NM normal mitochondria, SM pathological mitochondria