Fig. 3

The distance between mitochondria and endoplasmic reticulum is reduced resulting in increased number of MERCs in iNPH. a The endoplasmic reticulum (ER) and normal mitochondria (NM) are shown in a REF individual, also demonstrating the MERCs. b In an iNPH patient the MERCs is indicated. c The MERCs distance was shorter in iNPH. d At group level, the MERCs was 4.4-fold longer in REF than iNPH individuals (0.24 ± 0.04 µm vs. 0.06 ± 0.03 µm; P < 0.001; multivariate analysis). The length of ER was similar in the REF versus iNPH cohorts (0.67 ± 0.30 µm vs. 0.78 ± 0.43 µm, P = 0.65). Error bars are 95% CI. Magnification ×11,500; Scale bar 1 µm. CM clustered mitochondria