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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

Fig. 6

The uptake of [3H]amisulpride was determined in wildtype and 3×transgenic AD mice. Significant differences were observed for [3H]amisulpride between wildtype (n = 5 frontal cortex and n = 6 occipital cortex) and transgenic mice (n = 4 each region)—**p < 0.005. [3H]Amisulpride data have been corrected for [14C]sucrose. [14C]Sucrose uptake is shown. No differences in paracellular permeability and membrane integrity were observed. All data are expressed as mean ± S.E.M, n = 4–6 mice, 2 years old. Perfusion time was 10 min. 6 C57BL6/129 mice (3 males and 3 females: weight 37.0 ± 1.8 g) and 4 transgenic (2 males, 2 females: weight 29.1 ± 1.0 g) were used. Also see Additional file 1: Table S5

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