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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

Fig. 4

The effect of MATE1 inhibition on the accumulation of [3H]amisulpride (3.7–7.7 nM) was determined in hCMEC/D3 cell lines. Significant increases were observed compared to control ****p ≤ 0.0001, ***p ≤ 0.001, **p = 0.01 and *p = 0.05. [3H]amisulpride data has been corrected for [14C]sucrose and are expressed as mean ± S.E.M, n = 4 passages (p30 × 2, p31 and p34 for MATE1 inhibitor falmotidine at 1 μM and n = 3 passages for MATE1 inhibitor falmotidine at 2 μM) with 6 replicates (wells) per timepoint per plate (5 time-points)

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Fluids and Barriers of the CNS

ISSN: 2045-8118