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Table 2 CSF biomarker concentrations

From: Repeated lumbar punctures within 3 days may affect CSF biomarker levels

 

Recovery sleep

No sleep intervention

LP 1 x̄ a

LP 2 x̄

FC

p

LP 1 x̄

LP 2 x̄

FC

p

NFL

325

305

0.94

0.231

198

194

0.98

N/A

GFAp

183

188

1.03

0.641

236

231

0.98

N/A

T-tau

215

395

1.83

0.008

208

317

1.52

N/A

P-tau

39

59

1.51

0.006

31

43

1.39

N/A

Ab38

2640

3611

1.37

0.005

2353

2930

1.25

N/A

Ab40

7432

9434

1.27

0.006

6249

7117

1.14

N/A

Ab42

913

1198

1.31

0.003

719

878

1.22

N/A

YKL-40

56,718

72,363

1.28

0.039

56,978

71,639

1.26

N/A

  1. LP 1 x̄ and LP 2 x̄ represent average absolute concentrations in the first and second lumbar puncture, measured in pg/mL. p represents probability value calculated by paired two-tailed t-test
  2. YKL-40 chitinase-3-like protein, NFL neurofilament light, GFAp glial fibrillary acidic protein, T Tau total tau. P-tau phosphorylated tau FC fold change of each biomarker
  3. aPreviously published data [2]